The Persen House is located at 74 John Street in uptown Kingston within Kingston’s Stockade National Historic District. Its earliest portions date from c.1661 and it is one of four landmark buildings on each corner of John and Crown Streets. This is the only known intersection in the United States with pre-revolutionary stone houses on all four corners.

Metered parking lots and on-street parking are available throughout the uptown Kingston area on weekdays. The Ulster County Courthouse on Wall Street has limited availability during the week, but is completely available on the weekends. The Ulster County Office Building on the corner of Main & Fair Streets offers free weekend parking. There is also free parking at the Kingston Plaza every day, less than a half mile walk from the house.